CP-225,917 and CP-263,114 synthesis support studies: Testing a radical cyclization strategy for installation of the side-chains.


The selenocarbonate (I) has been prepd. and shown to react with hexabutyldistannane hydride/allyltributylstannane to give, via a radical cyclization/allylation sequence, the lactone (II) embodying vicinal and trans-related functionality likely to be appropriate for elaboration to the side-chains assocd. with the title compds., a.k.a. phomoidride A and phomoidride B, resp.

Australian Journal of Chemistry