Cubyl amides: Novel P2X7 receptor antagonists.

Abstract

CH2NHCOR1 [R = 1-adamantanyl, 1-cubyl; R1 = 2-FC6H4, 4-FC6H4, 2,5-Cl(MeO)C6H3] were synthesized and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesized compds. possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroceptor subtypes demonstrated their P2X7 selectivity.

Publication
Bioorganic & Medicinal Chemistry Letters
Date