A bidirectional synthesis of spiroacetals via Rh(II)-catalysed C-H insertion.

Abstract

Acyclic methylene acetals bearing two diazoester subunits were converted to [5,5]-spiroacetals via bidirectional C-H insertion under Rh(II) catalysis. Using a chiral Rh(II) catalyst, the major diastereomer was produced in high enantiomeric excess (89%).

Publication
Chemical Communications (Cambridge, United Kingdom)
Date