Rhodium(II)-catalyzed intramolecular C-H insertion α- to oxygen: reactivity, selectivity and applications to natural product synthesis.


A review. The selective functionalization of C-H bonds is a powerful strategy for the construction of organic molecules and the Rh(II)-catalyzed C-H insertion reaction is a particularly robust and useful tool for this purpose. This review discusses the insertion of Rh(II) carbenes into C-H bonds that are activated by α-oxygen substituents, focusing on the trends that have been observed in reactivity and selectivity, and the applications of this reaction to the total synthesis of complex natural products.

Organic & Biomolecular Chemistry