Synthesis and Evaluation of Anticancer Natural Product Analogues Based on Angelmarin: Targeting the Tolerance towards Nutrient Deprivation.

Abstract

A number of analogs of angelmarin were synthesized and evaluated for their ability to inhibit the tolerance of PANC-1 cells to survive nutrient deprivation. The most potent of the novel compounds was 8b (I) which possibly acts as a prodrug with improved cell permeability.