Stereocontrolled total synthesis of (+)-altohyrtin A/spongistatin 1.

Abstract

An enantioselective total synthesis of spongistatin 1, a.k.a. (+)-altohyrtin A, was achieved via a multistep synthetic sequence which included Wittig olefination, aldol condensation, and macrolactonization.

Publication
Angewandte Chemie, International Edition
Date