Total synthesis of altohyrtin A (spongistatin 1): an alternative synthesis of the CD-spiroacetal subunit.

Abstract

The CD-spiroacetal contg. C16-C28 subunit I, as used in the total synthesis of the potent cytotoxic macrolide altohyrtin A (spongistatin 1), was prepd. by an alternative route using substrate-based stereocontrol in the two aldol bond constructions generating the acyclic precursor II.

Publication
Tetrahedron Letters
Date