Total Synthesis of Spongistatin 1 (Altohyrtin A): A Tale of Ten Aldols.


A review on the total synthesis of spongistatin 1/altohyrtin A, an extremely rare marine macrolide with a seductively complex structure in combition with displaying promising anticancer properties. Topics covered include the retrosynthetic al.; the AB- and CD-spiroacetal subunit; the Northern and Southern hemisphere; Wittig coupling of the Northern and Southern hemispheres; and fil steps of structure-activity relationships.

Strategies and Tactics in Organic Synthesis